ODCs

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3 OMIM references -
3 associated genes
15 signs/symptoms

COMMON GENES: 1

1 OMIM reference -
1 associated gene
8 signs/symptoms

Primary pigmented nodular adrenocortical disease

Autosomal dominant striatal neurodegeneration

Citations in the biomedical literature:

Primary pigmented nodular adrenocortical disease		Autosomal dominant striatal neurodegeneration
	Synonym(s): - PPNAD		Synonym(s): - ADSD

	Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare infertility		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: any age Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adulthood Average age of death: - Type of inheritance: autosomal dominant

	External references: 3 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references

Primary pigmented nodular adrenocortical disease		Autosomal dominant striatal neurodegeneration
	Very frequent - Adrenal glands anomalies - Cortico-adrenal hyperplasia / hypersecretion Frequent - Asthenia / fatigue / weakness - Chronic arterial hypertension - Diabetes mellitus - Late puberty / hypogonadism / hypogenitalism - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Muscle weakness / flaccidity - Mutiple fractures / bone fragility - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets - Short stature / dwarfism / nanism - Striae - Thin skin - Truncal obesity Occasional - Myopathy		Very frequent - Autosomal dominant inheritance - Elocution disorders / dysarthria / dysphonia - Execution movement disorder / dysmetria / bradykinesia / akinesia / apraxia - Movement disorder - Muscle anomalies Frequent - Abnormal gait - Anomalies of tongue, gingiva and oral mucosa - Restricted joint mobility / joint stiffness / ankylosis